Karlie Guse’s disappearance has baffled investigators ever since the 16-year-old left her California home in the early morning hours of Oct. 13, 2018.
The night before, Karlie had been out partying with her friends and seemed disoriented when she came home. Her father, Zac Guse, suspected the marijuana she admitted smoking had been laced with another drug. Her stepmother, Melissa Guse, made an audio recording of Karlie to play for her when she started acting normally again, to show the teen how the drugs had impacted her.
But she never got the opportunity. That morning, while a concerned Melissa dozed off after spending hours in Karlie’s room with her, Karlie left the family’s rural Mono County home and never returned.
After she left home, Karlie was last seen by witnesses walking south approximately 30 yards east of Highway 6 and 100 yards south of Sierra View Road. But since then, there has been no trace of the teen who loved to spend time with her brothers and watch scary movies.
Her disappearance is the focus of tonight’s episode of People Magazine Investigates, titled “The Strange Disappearance of Karlie Gusé,” which airs on Investigation Discovery and streams on Max at 9/8c.
An exclusive clip from tonight’s episode is available on the internet. In the clip, Melissa recounts making a Facebook Live video 12 hours after Karlie vanished in the hopes that someone out there knew where she was.
Melissa says in the clip “I just wanted to get the word out and make it spread like wildfire, you know, social media, everybody’s on it.”
Further, she added “That night, we didn’t sleep at all, we just stayed up, hoping she’d be home the next day.”
On May 13, 2022, Karlie’s 20th birthday, the National Center for Missing and Exploited Children released an age-progression photo of what Karlie would look like today. At the time she went missing, Karlie was 5-foot-7-inches tall and weighed 110 lbs. She is a White female with blonde/brown hair and blue eyes.
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